quinta-feira, 3 de novembro de 2011

Música sobre a hemoglobina

O Natal já começa a aproximar-se e uma música de Natal bem conhecida (Santa Claus is Coming to Town) foi adaptada pelo Dr. Ahern (www.davincipress.com/metabmelodies.html) de forma a descrever o funcionamento da hemoglobina.

Hemoglobin's Moving Around
Oh isn't it great
What proteins can do
Especially ones that bind to O
Hemoglobin's moving around

Inside of the lungs
It picks up the bait
And changes itself from T to R state
Hemoglobin's moving around

The proto-porphyrin system
Its iron makes such a scene
Arising when an O binds
Pulling up on histidine

The binding occurs
Thanks to changes qua-ter-nar-y
Hemoglobin's moving around

It exits the lungs
Engorged with O
In search of a working body tissue
Hemoglobin's moving around

The proton concentration
Is high and has a role
Between the alpha betas
It finds imidazole

To empty their loads
The globins decree
"We need to bind 2,3BPG"
Hemoglobin's moving around

The stage is thus set
For grabbing a few
Cellular dumps of CO
Hemoglobin's moving around

And then inside the lungs it
Discovers ox-y-gen
And dumps the CO off
To start all o'er agin

So see how this works
You better expect
To have to describe the Bohr effect
Hemoglobin's moving around

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