Música sobre a gluconeogénese

Kevin Ahern (www.davincipress.com/metabmelodies.html) é um professor da Oregon State University que criou várias músicas sobre a bioquímica para os seus alunos. Aqui fica a letra da música sobre a gluconeogénese (baseada na música Supercalifragilisticexpialidocious) e o link para o download do respectivo ficheiro mp3.

http://www.mediafire.com/?8rwy9fzwg2ou9rm

When cells have lots of ATP and NADH too

They strive to store this energy as sugar yes they do

Inside of mitochondria they start with pyruvate

(slow) Carboxylating it to make oxaloacetate

Oh gluconeogenesis is so exhilarating

Memorizing it can really be exasperating

Liver cells require it so there’s no need for debating

Gluconeogenesis is so exhilarating

Oh, glucose, glucose come to be

Glucose, glucose come to be

Oxaloacetate has got to turn to PEP

Employing energy that comes from breaking GTP

From there it goes to make a couple phosphoglycerates

(slow) Exploiting ee-nolase and mutase’ catalytic traits

Oh gluconeogenesis is liver’s specialty

Producing sugar for the body most admirably

Six ATPs per glucose is the needed energy*

Gluconeogenesis is liver’s specialty

Oh glucose, glucose joy to me

Glucose, glucose joy to me

Converting phosphoglycerate to 1,3BPG

Requires a phosphate that includes A-T-P energy

Reduction with electrons gives us all an N-A-D

(slow) G3P’s isomerized to make D-H-A-P

Oh gluconeogenesis is anabolic bliss

Reversing seven mechanisms of glycolysis

To do well on the final students have to learn all this

Gluconeogenesis is anabolic bliss

Oh, glucose, glucose factory

Glucose, glucose factory

The aldolase reaction puts together pieces so

A fructose molecule is made with two phosphates in tow

And one of these gets cleaved off by a fructose phosphatase

(slow) F2,6BP's acting blocking path-a-waysAnd

Oh gluconeogenesis a pathway to revere

That makes a ton of glucose when it kicks into high gear

The cell's a masterminding metabolic engineer

Gluconeogenesis a pathway to revere

Oh glucose, glucose jubilee

Glucose, glucose jubilee

From F6P to G6P, that is the final phase

The enzyme catalyzing it is an isomerase

Then G6P drops phosphate and a glucose it becomes

(slow) Inside the tiny endoplasmic-al reticulumsUnless

Oh gluconeogenesis is not so very hard

I know that on the final we will not be caught off guard

'Cause our professor lets us use a filled out index card

Gluconeogenesis is not so very hard

*Actually, you need two NADHs too, but that wouldn't fit the rhyme